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recombinant aav vectors  (Shanghai Genechem Ltd)

 
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    Shanghai Genechem Ltd recombinant aav vectors
    Recombinant Aav Vectors, supplied by Shanghai Genechem Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+aav+vectors/pmc12948558-146-1-4?v=Shanghai+Genechem+Ltd
    Average 86 stars, based on 1 article reviews
    recombinant aav vectors - by Bioz Stars, 2026-08
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    Knockdown of IRF8 alleviates lung injury in COPD mice. COPD model mice were intratracheally administered with corresponding adeno-associated virus to interfere with IRF8 expression. ( A ) Lung index calculated as lung weight/body weight. ( B - E ) Assessment of emphysema in lung tissue by H&E staining. B: Representative H&E-stained images; C: Mean alveolar number; D: Mean linear intercept; E: Airway inflammation score based on inflammatory cell infiltration. ( F ) Real-time PCR analysis of IRF8 expression in lung tissue. ( G ) Western blot analysis of IRF8 protein levels in lung tissue. ( H - L ) Giemsa staining and quantification of total leukocytes ( H ), neutrophils ( I ), Eosinophil ( J ), macrophages ( K ), and lymphocytes ( L ) in bronchoalveolar lavage fluid (BALF). ( M - O ) ELISA detection of TNF-α (M), IL-1β ( N ), and IL-1α ( O ) levels in lung tissue. N = 6 replicates

    Journal: Inflammation

    Article Title: IRF8 and FOXM1 Regulation in COPD Progression: Impacts on Inflammation and Senescence

    doi: 10.1007/s10753-026-02474-x

    Figure Lengend Snippet: Knockdown of IRF8 alleviates lung injury in COPD mice. COPD model mice were intratracheally administered with corresponding adeno-associated virus to interfere with IRF8 expression. ( A ) Lung index calculated as lung weight/body weight. ( B - E ) Assessment of emphysema in lung tissue by H&E staining. B: Representative H&E-stained images; C: Mean alveolar number; D: Mean linear intercept; E: Airway inflammation score based on inflammatory cell infiltration. ( F ) Real-time PCR analysis of IRF8 expression in lung tissue. ( G ) Western blot analysis of IRF8 protein levels in lung tissue. ( H - L ) Giemsa staining and quantification of total leukocytes ( H ), neutrophils ( I ), Eosinophil ( J ), macrophages ( K ), and lymphocytes ( L ) in bronchoalveolar lavage fluid (BALF). ( M - O ) ELISA detection of TNF-α (M), IL-1β ( N ), and IL-1α ( O ) levels in lung tissue. N = 6 replicates

    Article Snippet: Recombinant adeno-associated virus (AAV) vectors were constructed and produced using the shuttle plasmid pAV-U6-shRNA-CMV-RFP (Vigene Biosciences, pAV100004-KD).

    Techniques: Knockdown, Virus, Expressing, Staining, Real-time Polymerase Chain Reaction, Western Blot, Enzyme-linked Immunosorbent Assay